H6649
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H6649
Sigma
Herbimycin A from Streptomyces hygroscopicus
≥95% (HPLC), powder
| CAS Number: | 70563-58-5 |
| Linear Formula: | C30H42N2O9 |
| Molecular Weight: | 574.66 |
| Beilstein Registry Number: | 4834067 |
| MDL number: | MFCD00151702 |
| PubChem Substance ID: | 24895756 |
Description
| Biochem/physiol Actions | An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis. |
| Caution | Hygroscopic and photosensitive |
Properties
| assay | ≥95% (HPLC) |
| form | powder |
| color | yellow |
| solubility | DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1. |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | LX8930000 |
References
| reference | Davis, et al., Herbimycin A and geldanamycin inhibit okadaic acid-induced apoptosis and p38 activation in NRK-52E renal epithelial cells. Toxicol. Appl. Pharmacol. 16, 59-74, (1999) |
| Zakar, et al., Tyrosine kinase inhibitors block the glucocorticoid stimulation of prostaglandin endoperoxide H synthase expression in amnion cells. Can. J. Physiol. Pharmacol. 77, 138-142, (1999) Abstract | |
| Nagaishi, et al., Herbimycin A inhibits both dephosphorylation and translocation of cofilin induced by opsonized zymosan in macrophagelike U937 cells. J. Cell Physiol. 180, 345-354, (1999) Abstract | |
| Oikawa, T., et al., Possible functional groups responsible for inhibition of in vivo angiogenesis by herbimycin A. Biol. Pharm. Bull. 17, 1430-1432, (1994) Abstract |
